'In Spite of Ourselves' is the 13th studio album of John Prine, featuring duets with various well-known female folk and alt-country vocalists, released in 1999.

The album was Prine's first release since successfully battling throat cancer. The female duet partners include Iris DeMent, Connie Smith, Lucinda Williams, Melba Montgomery, Emmylou Harris, Trisha Yearwood, Dolores Keane, Patty Loveless, and his wife, Fiona Prine.

1. (We're Not) The Jet Set (feat. Iris DeMent)
2. So Sad (To Watch Good Love Go Bad) (feat. Connie Smith)
3. Wedding Bells/Let's Turn Back the Years (feat. Lucinda Williams)
4. When Two Worlds Collide (feat. Trisha Yearwood)
5. Milwaukee, Here I Come (feat. Melba Montgomery)
6. I Know One (feat. Emmylou Harris)
7. It's a Cheating Situation (feat. Dolores Keane)
8. Back Street Affair (feat. Patty Loveless)
9. Loose Talk (feat. Connie Smith)
10. Let's Invite Them Over (feat. Iris DeMent)
11. 'Til a Tear Becomes a Rose (feat. Fiona Prine)
12. In A Town This Size (feat. Dolores Keane)
13. We Could (feat. Iris DeMent)
14. We Must Have Been Out of Our Minds (feat. Melba Montgomery)
15. In Spite Of Ourselves (feat. Iris DeMent)
16. Dear John (I Sent Your Saddle Home)

John Prine - In Spite Of Ourselves

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